产品号 #100-0754_C
Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2)
概述
The AC18F antibody reacts with angiotensin-converting enzyme 2 (ACE2), a type I integral membrane protein, which includes a short C-terminal cytoplasmic domain made of 22 amino acids, a transmembrane domain, and a large N-terminal ectodomain made of 740 amino acids. The N-terminal domain of ACE2 contains a catalytic zinc-binding motif, which shares a 42% similarity to the catalytic binding domain of ACE. Despite the similarity in catalytic domains, ACE2 functions as a carboxypeptidase, while ACE functions as either a peptidyl dipeptidase or an endopeptidase. In humans, ACE2 is a key regulator of the renin-angiotensin system, where it catalyzes the cleavage of the vasoconstrictor peptide angiotensin II to angiotensin 1-7. Expression of ACE2 can be found on endothelial cells throughout the body, such as in the kidney, heart, and lungs. In the airways leading to the lungs, ACE2 provides the main entry point for SARS-CoV-2 (2019-nCoV). Once the SARS-CoV-2 Spike Protein binds to ACE2, viral fusion with the host cell membrane can occur, resulting in viral RNA genome delivery.
Target Antigen
Angiotensin-Converting Enzyme 2
Alternative Names
SARS Receptor, Angiotensin-converting Enzyme 2, ACEH, Metalloprotease MPROT15, SARS-CoV-2 Receptor
Reactive Species
Human
Conjugation
ATTO 488, ATTO 647N, Biotin, Unconjugated
Host Species
Mouse
Cell Type
Airway Cells, Epithelial Cells
Application
ELISA, Flow Cytometry, Western Blotting
Area of Interest
Disease Modeling, Epithelial Cell Biology, Respiratory Research
Clone
AC18F
Gene ID
59272
Isotype
IgG1, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (6)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
