产品号 #07980_C
细胞培养添加物
概述
肝素是一种具有抗凝血特性的粘多糖。它支持成纤维细胞生长因子（FGF）与其受体的结合，并增加了FGF的稳定性。肝素与表皮生长因子（EGF）和FGF一起在NeuroCult™培养基中用于培养胚胎大鼠或成人神经干和祖细胞，以及成年小鼠神经干和祖细胞。如需完整说明，请参阅技术手册：使用NeuroCult™(Human；文档#28724或小鼠/大鼠；文件#28725)，可在www.stemcell.com或联系我们索取副本。
肝素溶液也需要作为各种其他STEMCELL培养基的补充，包括乳腺细胞™人培养基试剂盒（目录#05620），EpiCult™-B小鼠培养基试剂盒（目录#05610），和EC-Cult™-XF培养试剂盒（目录#08000）。
Contains
0.2% (2 mg/mL; 360 IU/mL) Heparin sodium salt in phosphate-buffered saline (PBS)
Subtype
Supplements
Cell Type
Mammary Cells, Neural Stem and Progenitor Cells, Other, Prostate Cells
Species
Human, Rat
Application
Cell Culture
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
Publications (1)
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro-oncology 2011 SEP
Abstract
Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine animal studies, we serendipitously observed that fenbendazole, a benzimidazole antihelminthic used to treat pinworm infection, inhibited brain tumor engraftment. Subsequent in vitro and in vivo experiments with benzimidazoles identified mebendazole as the more promising drug for GBM therapy. In GBM cell lines, mebendazole displayed cytotoxicity, with half-maximal inhibitory concentrations ranging from 0.1 to 0.3 µM. Mebendazole disrupted microtubule formation in GBM cells, and in vitro activity was correlated with reduced tubulin polymerization. Subsequently, we showed that mebendazole significantly extended mean survival up to 63% in syngeneic and xenograft orthotopic mouse glioma models. Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe human use, and was effective in our animal models with doses documented as safe in humans. Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials.
更多信息
| Species | Human, Rat |
|---|---|
| Contains | 0.2% (2 mg/mL; 360 IU/mL) Heparin sodium salt in phosphate-buffered saline (PBS) |
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
