Thiamet G selectively inhibits O-GlcNAcase (Ki = 21 nM; Yuzwa et al.), an enzyme that removes O-linked β-N-acetylglucosamine (O-GlcNAc) from proteins; this inhibition of O-GlcNAcase blocks phosphorylation of the tau protein in vivo (Gong & Iqbal). Pathological hyperphosphorylation of the tau protein can aggregate and induce the formation of neurofibrillary tangles, which is a hallmark of Alzheimer’s disease (Gong & Iqbal; Yuzwa et al.). Thiamet G is blood-brain barrier permeable and can be used to study the function of O-GlcNAc in the vertebrate brain (Yuzwa et al.).
DISEASE MODELING
· Decreases phosphorylation of tau in rats (Yuzwa et al.).
DISEASE MODELING
· Decreases phosphorylation of tau in rats (Yuzwa et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Thiamet G
Catalog #
100-0883
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Thiamet G
Catalog #
100-0883
Lot #
All
Language
English
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