Inhibit cancer cell growth by selectively inhibiting poly ADP ribose polymerase (PARP) with olaparib. With a high affinity for both PARP1 and PARP2 (IC50 = 5 and 1 nM), olaparib is an inhibitor of PARPs in cancer cells with BRCA1 or BRCA2 mutations (Menear et al.). PARPs are a family of enzymes that repair DNA breaks by assisting with base excision repair (BER); olaparib inhibits this activity, leading to DNA damage and cell death (Davar et al.).
Olaparib has been used for:
CANCER RESEARCH
· Inhibits tumor growth and overall survival in ATM-deficient mantle cell lymphoma cells (Williamson et al.).
· Inhibits growth of esophageal squamous cell carcinoma cells by cell cycle arrest at G2/M (Nasuno et al.).
· Induces anti-proliferative effects in specific endometrial cancer cell lines (Miyasaka et al.).
· Reported as a potentially effective therapeutic agent against epithelial ovarian cancer (Chen & Du).
· Prevents or partially reverts epithelial-mesenchymal transition (EMT) induced by TGF-β in NMuMG cells (Schacke et al.).
· Reported to prevent OVA-induced airway inflammation and remodeling through modulation of inflammasome signaling in mice (Sethi et al.).
Olaparib has been used for:
CANCER RESEARCH
· Inhibits tumor growth and overall survival in ATM-deficient mantle cell lymphoma cells (Williamson et al.).
· Inhibits growth of esophageal squamous cell carcinoma cells by cell cycle arrest at G2/M (Nasuno et al.).
· Induces anti-proliferative effects in specific endometrial cancer cell lines (Miyasaka et al.).
· Reported as a potentially effective therapeutic agent against epithelial ovarian cancer (Chen & Du).
· Prevents or partially reverts epithelial-mesenchymal transition (EMT) induced by TGF-β in NMuMG cells (Schacke et al.).
· Reported to prevent OVA-induced airway inflammation and remodeling through modulation of inflammasome signaling in mice (Sethi et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Olaparib
Catalog #
100-1169
Lot #
All
Language
English
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Resources and Publications
Educational Materials (3)
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