Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90) (Schulte et al.; Whitesell et al.). It inhibits the ATPase activity of Hsp90 by binding with high affinity to the N-terminal ATP-binding site (Kd = 1.2 µM; Roe et al.). Geldanamycin also binds to the glucose-regulated protein GRP94, an endoplasmic reticulum protein with homology to Hsp90. This interaction destabilizes its complex with p185-ERBB2 leading to degradation of ERBB2 protein, which is overexpressed in aggressive breast cancers (Chavany et al.; Castagnola et al.).
CANCER RESEARCH
· Inhibits growth of 60 human tumor cell lines (Supko et al.).
DISEASE MODELING
· Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.).
· Inhibits replication of HSV-1 and HSV-2 (Li et al.).
CANCER RESEARCH
· Inhibits growth of 60 human tumor cell lines (Supko et al.).
DISEASE MODELING
· Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.).
· Inhibits replication of HSV-1 and HSV-2 (Li et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Geldanamycin
Catalog #
74034, 74032
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Geldanamycin
Catalog #
74034, 74032
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Monocyte Research
Resources and Publications
Educational Materials (4)
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